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Why Colossal Bioscience revived the dire wolf

The infamous company, Colossal Biosciences, has unveiled its first resurrected species that vanished from the Earth 10,000 years ago.

When we think of de-extinction, our minds immediately go to Jurassic Park, and our imaginations run wild with the potential consequences of such a scenario.

Colossal Biosciences has gone against Michael Crichton’s cautionary tale of human ambition, nonetheless, with its efforts to bring back long-gone species. Unsurprisingly, many doubted the company’s efforts, questioning if Colossal was another Theranos.

Yet, against all odds, the company did the unimaginable and resurrected a species – the dire wolf. Made famous by the hit series Game of Thrones, dire wolves ceased to exist approximately 10,000 years ago.


A brief history of dire wolves

Native to the Americas, the first fossil specimen of this apex predator was found in 1854 in Indiana, USA. Since then, thousands of these fossils have been discovered with a high saturation in Los Angeles.

Remains have also been found across a wide range of habitats in North and South America, from Canada to Mexico and into parts of South America like Venezuela, Peru, and Bolivia.

 

Dire wolves were similar in size to large modern gray wolves but were more heavily built, with a huge skull, larger teeth, and a stronger jaw. For a long time, it was believed that dire wolves were closely related to gray wolves. However, recent genetic studies of ancient DNA have revealed a surprising twist.

These studies indicate that dire wolves were not closely related to gray wolves or any other living canids. Instead, they represent a distinct evolutionary lineage that diverged millions of years ago in North America.

Their extinction was the result of a combination of factors such as the extinction of their prey, climate change, and increased competition.


Colossal’s revival efforts

Just a few days ago, the company revealed the successful birth of three dire wolf pups – Romulus, Remus, and Khaleesi, taking everyone by surprise. Scientists extracted high-quality DNA from dire wolf fossils and combined it with the genome of a gray wolf.

Currently, the wolves are housed in a secure 2,000-acre nature preserve equipped with specialized engagement zones to ensure optimal welfare. Colossal has received the American Humane Society certification for its commitment to animal care.

It’s vital to emphasise that the company did not bring back the same dire wolves that roamed around the Americas more than 10,000 years ago. As mentioned earlier, the species had a distinct genetic lineage; hence, the dire wolves that Colossal resurrected are not a true representation of the extinct species.


What is the company’s agenda?

Why bring back a long-extinct species, with uncertainty about how it’s going to assimilate into modern ecosystems.

Well, Colossal has one goal in mind – to improve the ongoing loss of biodiversity and restore ecological balance. With initially announced projects such as the Woolly Mammoth, Dodo, and Tasmanian Tiger, the company plans to fill empty ecological roles left by extinct species.

For instance, the woolly mammoth’s role in maintaining Arctic grasslands or the dodo’s role in island ecosystems. What about the dire wolf?

The answer lies with North Carolina’s red wolves. This species is one of the most endangered wolves globally, with fewer than 20 surviving in the wild and about 200 in captivity. Their population has been declining due to threats such as habitat loss, vehicle collisions, and hunting.

In fact, Colossal has cloned four red wolf-coyote hybrids, removing most of the coyote DNA to create animals that closely resemble red wolves. These clones are intended to enhance genetic diversity within captive populations, which is crucial for their survival.

The dire wolf project allowed Colossal to refine advanced genetic tools, such as CRISPR and non-invasive cloning techniques. These innovations are directly applicable to conserving endangered species, including red wolves, by enhancing genetic diversity and overcoming ‘genetic bottlenecks’ in small populations.

Dire wolves were apex predators in the Late Pleistocene, hunting large prey like bison and horses. Their extinction left an ecological gap Colossal aims to fill with resurrected proxies – like wolves reintroduced to Yellowstone, which transformed the ecosystem by restoring balance and boosting biodiversity.

By filling the niche left by extinct megafaunal predators, dire wolves may contribute to healthier ecosystems, especially in areas where large prey species still exist.

The company’s goal to save current species using ancient ones is remarkable, but models can only predict so much. With the first de-extinct species now here, only time will reveal its true impact and whether it sparks a revolution or sets us back.

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