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This eye implant could cure blindness for millions of people

Scientists in Sweden have developed a bioengineered cornea that can successfully restore sight. It’s made from proteins in pigskin, which are a by-product of the food industry.

For the millions of people across the globe who are blind or have impaired sight as a result of damage to their corneas (a progressive condition known as keratoconus), a breakthrough development from scientists in Sweden may pose a solution.

One that’s both environmentally friendly and financially viable given transplant procedures to replace the clear outer later protecting and focusing light to the eyes can be expensive, invasive, and time-consuming.

I’m talking about the development of artificial bioengineered corneas made from proteins in pigskin, which are a widely available food industry by-product containing collagen.

Pigs have recently been the go-to for other potential transplants to human patients, such as kidneys and hearts. Genetic engineering has made it possible to change molecules in the pig cells to prevent an immune response and organ rejection in human recipients.

Thanks to researchers at Linköping University, the twenty Indian and Iranian participants in the trial who were blind or on the verge of being so have had some or all of their sight restored, with three reporting to now have 20/20 vision.

The cornea implant made of collagen protein from pig's skin which can restore sight to the blind and visually impaired

With this looking to end our reliance on human donors and cure the blindness of a substantial portion of the world’s population, the findings are indeed promising.

Particularly because, at present, an estimated 12.7 million people are on waiting lists for cornea transplants.

‘The operations were free from complications; the tissue healed fast; and an eight-week treatment with immunosuppressive eye drops was enough to prevent rejection of the implant,’ a press release for the study reads.

‘With conventional cornea transplants, medicine must be taken for several years. The patients were followed for two years, and no complications were noted during that time.’

Alongside limited donor availability, the typical treatment also risks graft rejection, healing complications, infections, astigmatism, and the need for long-term support.

Photographs of a patient's cornea before operation (left) and one day post-operation (right) with arrows indicating change in thickness and curvature in the central cornea. (Credit: Rafat M et all/2022)

The new method, however, allows doctors to insert the implant into the existing cornea, requires no stitches, and incision is minimally invasive with either an advanced laser or by hand.

Not only this, but in addition to the landmark procedure results, the new corneas are far more accessible than organ donations as they can be stored for two years rather than just two weeks.

‘Bioengineering implantable tissue is the key to addressing the global burden of corneal blindness,’ continues the press release, which states that researchers must still perform a larger clinical study before the pigskin implants (fashioned to look like a contact lens) can be formally approved and used in health care.

‘We’ve made significant efforts to ensure that our invention will be widely available and affordable by all and not just by the wealthy. We really designed this material and technology and surgical procedure to be adopted in areas of the world where there are really low resources.’

‘Those are the same areas of the world where the burden of blindness due to this disease is the highest.’

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