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Does the human brain have a microbiome?

Though it’s long been assumed that bacteria can’t survive in the human brain, neuroscientists have recently been surprised to discover that it may harbour all sorts of micro-organisms.

In recent years, gut health has been all the rage.

This is because our understanding of the function and importance of the microbiome that lives in our intestines has improved, particularly in relation to maintaining the immune system.

A microbiome is a community of microorganisms, such as bacteria, fungi, and viruses, that live on or inside a particular environment. Others have been discovered too, in the lungs, nasal cavity, skin, and even scalp.

What’s long been dismissed, however, is the possibility of one able to survive in the human brain.

This is due to the widespread belief that it’s a sterile organ, shielded – by the powerful blood-brain barrier – from the rest of the body and from harmful ‘agents’ that are circulating in our blood.

It’s also due to the difficulty of obtaining healthy, uncontaminated human brain tissue that could be analysed in order to confirm the presence of microbes.

Research during the last decade has sought to untangle this web, with a study published in Science Advances providing the strongest evidence yet that this is something to look into.

As it uncovered, the brain microbiome can and does exist in healthy vertebrates – specifically, fish.

And not only do these communities of bacteria have special adaptations that allow them to survive in brain tissue, but techniques that help them cross the protective threshold.

‘This is concrete evidence that brain microbiomes do exist in vertebrates,’ says physiologist, Matthew Olm. ‘And so the idea that humans have a brain microbiome is not outlandish.’

Apparently taking note of this statement, neuroscientists set out to examine whether diseases like Alzheimer’s – which makes the blood-brain barrier leaky so it lets in damaging substances – had any effect.

They found that the brains of people with Alzheimer’s harboured more bacteria and fungi than healthy people, but they also found several species of fungi, bacteria, and other microorganisms in the brains of healthy people.

It remains unclear how exactly this is happening, but some theorise that poor oral hygiene is responsible as it causes tissue damage and allows bacteria to travel to the brain via the nervous system.

On this note, proponents of the idea that the human brain has a microbiome are both hopeful that it could open the door to new potential treatment options for intractable diseases like Alzheimer’s and keen to get the ball rolling on raising awareness about this so that people can start taking better care of their mouths and, consequently, their minds.

‘The best immune-boosting advice we can glean from the literature includes good diet, exercise and good general health, watching things as we age like blood sugar and cholesterol, and implementing what is mostly common sense,’ says Nikki Schultek, whose neurological disorder turned out to be caused by microbes in the brain and who recently lead-authored a paper about this.

‘This includes avoiding an ultra-processed diet, which not only helps with inflammation, but may also help to enhance immune function.’

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